Psychedelic drugs such as LSD (lysergic acid diethylamide), psilocybin and ketamine have been rediscovered by researchers in neuroscience and psychiatry. A recent review in the Journal of Psychopharmacology highlights the distinct therapeutic effects of psychedelics, as well as the current re-evaluation of their use in the treatment of addiction, anxiety in terminally ill patients, depression, cluster headaches and obsessive-compulsive disorder (OCD).A psychedelic drug is a psychoactive drug whose primary action is to alter cognition and perception. Since the discovery of LSD in 1943, psychedelic drugs have been of major scientific interest. Despite clinical psychedelic research coming to a standstill in the mid-1970s (due to regulatory restrictions), an increase in methodological quality standards, neurobiological method and neuroimaging, as well as interest in the interest of the neurosciences in subjective experience, has meant a re-emergence of interest.The review by Tomislav Majić (Charité University Medicine, Berlin), Timo Schmidt (Free University Berlin) and Jürgen Gallinat (University Medical Center Hamburg-Eppendorf), looked at current clinical research and re-evaluated former and recent concepts of where and how psychedelic substances exert their therapeutic effects. Share on Twitter Share on Facebook Email Pinterest LinkedIn Share Key findings included that ketamine is effective in the treatment of substance addiction, both through the psychedelic experiences and it’s enhancing of personal meaning and spiritual significance. Ketamine has also been used to produce short-term anti-depressive effects in major depression and bipolar disorder, through its altering of perception (It has also been proposed as a treatment option for affective disorders based on its pharmacological effects).LSD has been shown to be beneficial in the treatment of alcohol abuse when used in combination with therapy.Psilocybin, the main component of so-called magic mushrooms, has been recently shown to be effective in the treatment of anxiety in cancer patients, not by reducing pain, but by inducing feelings of strengthened rapport and relationships with close relatives and friends. Recent research has also highlighted the therapeutic use of LSD and psilocybin in treating cluster headaches. Interestingly, it was reported that the therapeutic effects appear to be completely independent of the psychedelic experience.The review reported converging evidence suggesting that serotonergic neurotransmission plays a key role in the mechanism of these psychedelic drugs – the neurotransmitter serotonin is thought to play an important role in the brain relating to mood, anxiety and happiness.The findings of the review concluded that psychedelic drugs are unique in the sense that they: have neurochemical and pharmacodynamics effects (e.g. in the treatment of depression and possibly OCD); support various types of psychotherapy (e.g. in the treatment of terminal illness); can be used to treat headaches or other pain syndromes; and they often result in spiritual experiences through which they can assist in therapy (e.g. in the treatment of substance addiction). Furthermore, in contrast to traditional psychiatric drugs, they are only to be taken once or a few times.The review highlights the potential for psychedelic drugs to be used in clinical settings, although more research is required to develop a deeper understanding of their therapeutic effects and how they work.
COUNTY News:Crews from Los Alamos County Traffic and Streets Department, working in conjunction with local police officers, will assist in the transport of an oversized load between 6-7 a.m. Monday. During the morning hours, the transport company will be moving the load from the bottom of Totavi Hill, up N.M. 502 to DP Road. Motorists should be cautious around this oversized load and expect minimal delays along the route.
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The pilot’s difficulty in controlling the bulk carrier Conti Peridot’s heading was identified as the probable cause of the collision between the bulker and the tanker Carla Maersk in the Houston Ship Channel in March 2015, according to the National Transportation Safety Board (NTSB).Besides the inability of the pilot on the Conti Peridot to respond appropriately to hydrodynamic forces after meeting another vessel during restricted visibility, other factors are believed to have led to the collision, among which is the lack of communication with other vessels about the handling difficulty.Contributing to the circumstances was the inadequate bridge resource management between the master and the pilot on the Conti Peridot, as they did not work together to solve the problem.Furthermore, lack of predetermined ship movement strategies during restricted visibility in the Houston Ship Channel also played a role in the collision.“On the day of the accident, local pilot associations determined that the increasing fog was significant enough to suspend pilot boardings of inbound ships. However, piloted vessels already under way continued the transit in the fog,” NTSB said, adding that the Vessel Traffic Service Houston/Galveston did not effectively monitor vessel traffic to identify the developing risk of collision during restricted visibility.Image Courtesy: USCGAs a result of this accident, the NTSB issued safety recommendations to Bremer Bereederungsgesellschaft mbH & Co., the Conti Peridot’s operating company, the Houston Pilots Association, and the Lone Star Harbor Safety Committee.The two vessels collided in restricted visibility on March 9, 2015, near Morgan’s Point, Texas, when the bulker crossed the channel into the path of the Carla Maersk.There were no injuries in the collision, but an estimated 88,200 gallons of methyl tert-butyl ether spilled from the Carla Maersk, and the two vessels sustained about USD 8.2 million in total damage.
Cape Town Baroque Festival director Erik Dippenaar and Ralitza Macheva on baroque violin at last years festival. Now in its third year, the Cape Town Baroque Festival (CTBF) will be held from Wednesday September 18 to Tuesday September 24 at various venues. Themed “Diversity in Early Music”, the 2019 festival celebrates the variety of styles and genres of music from the Baroque period.This year’s festival will be the first time that concerts will be held in the Zeitz Museum of Contemporary Art Africa (MOCAA) at the V&A Waterfront and Youngblood Gallery in Bree Street. Also, it is the first time that a newly composed work will be performed – a reimagining of JS Bach’s Brandenburg Concerto No.3 by local composer Hans Roosenschoon.The festival’s premier concert is Big Bach Bonanza! on Friday September 20 in the Evangelical Lutheran Church in Strand Street, at 8pm.It includes a variety of compositional genres that Bach used and brings together a large group of baroque specialists, directed by harpsichordist and festival director Erik Dippenaar.The concert features international soloists Erik Bosgraaf (recorder) and Raphael Pouget (natural trumpet), who will also perform in Chamber Baroque on Saturday September 21 at the Baxter Concert Hall, at 7.30pm. For the Chamber Baroque concert, Anna Stoddard will present a pre-concert talk about this unique programme of 18th century chamber music at 6.30pm in the concert hall.Another unique performance on this year’s programme is a demonstration of the carillon in the Cape Town City Hall tower by Alexios Vicatos. Three guest ensembles will present diverse programmes. The Flat Mountain Project, a team of musicians who collaborate on projects that showcase modern and experimental classical music, can be heard in Four Seasons Recomposed.The ensemble Here Be Dragons, led by instrumentalist and composer Jan-Hendrik Harley, explores folk music performed in and around the main cultural centres in Europe during the 15th and 16th century in the concert Folk101.The Lutesong Duo – Lente Louw (mezzosoprano) and Uwe Grosser (theorbo, lute, baroque guitar) – teams up with fellow musicians for Musica Rustica, a programme of light vocal music from Renaissance Italy that will be paired with Neapolitan-inspired canapés at the 6 Spin Street Restaurant.Since its inception, the CTBF has invested in upcoming local players of baroque music, and this year young recorder players and pupils from the Ronnie Samaai Music Education Project will receive master classes from Bosgraaf. For more information, visit www.ctbaroque.co.za/festival or email email@example.com Tickets can be bought through Webtickets, Pick * Pay stores or at the door.Festival passes are available at R580 each by emailing firstname.lastname@example.org
International Monetary Fund (IMF) managing director, Christine Lagarde is in Nigeria on a 4-day visit to advise Africa’s largest oil producer on how to recover from the shock of falling oil prices on the international market.The oil price has slid to $37 a barrel, a tough feat for Nigeria where 70% of revenue is realized through oil sales internationally.Lagarde is meeting with President Muhammadu Buhari and newly installed Finance Minister Kemi Adeosun.The Nigerian President recently announced a record budget for 2016. He plans to triple expenditure in a move to help the country adjust to the downturn in oil, which lost almost two-thirds of its value in the last year.Nigeria’s Central Bank has also issued a directive restricting the use of debit and credit cards abroad as a temporary measure to limit the flow of foreign currency out of the country.Nigeria’s currency Naira has also weakened further against the dollar, this on the heels of a forecast that announced a budget deficit of 2.2 trillion naira, about $11-billion.Lagarde will deliver a speech to lawmakers from Nigeria’s National Assembly and will also meet with business leaders during the visit. Also on the agenda for the IMF chief is a meeting with finance ministers from the six member nations of the economic and monetary community of Central Africa – CEMAC – she’ll address hat group on January 8th.
LocalNews Dominica PM wants more debate on marijuana issue by: Caribbean Media Corporation – March 11, 2015 Share ROSEAU, Dominica, (CMC) – Dominica Prime Minister Roosevelt Skerrit says he is not completely sold on the idea of decriminalising small amounts of marijuana as regional countries debate the issue.Speaking on the state-owned DBS radio, Skerrit asked what would be done with the “excess’ if the authorities agree to enact legislation allowing for the use of small quantities of the illegal drug.“What do you do with the excess, and you don’t want to be encouraging the trafficking of this drug to other countries and what would be your relationship with the rest of the world?”He said, in Colorado in the United States where the drug has been decriminalised concerns are being raised by many other states “about the amount of marijuana coming from Colorado to their own states and is creating a problem for them.“I think it is important for us to have a discussion, there is nothing wrong in discussing, there is nothing wrong in having various views and approaches but I think it is important for us to have the discussion. All I would say is that when one makes a suggestion, when one makes a recommendation, one has to take many other things into consideration”.Prime Minister Skerrit said it is not just about legalising the drug, but “it is about having a serious discussion and allowing different views to contend and let us see what is the best way forward.“But I think it is important for us to look at taking small steps with regards to the marijuana issue,” he told radio listeners.Last month, Barbados Prime Minister Freundel Stuart said that Caribbean leaders had established a committee to examine all issues of the marijuana debate since regional countries would not want to wake up one morning and have to be importing marijuana from the United States where the product has been decriminalized in some states.He acknowledged that the region was being spurred forward by the developments unfolding in North America.“For some time we have been lectured…about the illegality and the undesirability and all other negatives about marijuana. But then all of a sudden we are hearing from those same sources that there is nothing as wrong with it as they had first thought,” he said.Stuart, who will take over the chairmanship of the regional grouping in July, told reporters that “there has been a concern if we remain asleep too long, when we in fact wake up from our slumber we will be importing marijuana from the United States of America rather than making effective use of our own”.But Prime Minister Stuart was clear to indicate that “this is not to say that we [are] going to blindly rush into legalising marijuana”. Share Tweet 190 Views one comment Share Sharing is caring!
Juvic Pangunsan raises his hands after winning the ICTSI Negros Occidental Classic on Saturday at the Negros Occidental Golf and Country Club course. ICTSI NEGRENSE Juvic Pangunsan showed poise and class in the playoff feet to clinch the victory in the ICTSI Negros Occidental Classic on Saturday at the Negros Occidental Golf and Country Club course.Dragged into a playoff by Jobim Carlos, Pagunsan struck a solid wedge shot from 60 yards to within 5 feet on the second extra hole and made the putt. He then watched Carlos muff his own birdie bid to clinch the crown.Pangunsan, a native of Murcia, Negros Occidental, closed out the three-day event with a 67 for a nine-under 271 total, which Carlos matched with a 68 on a birdie-par-birdie windup.“It was an inspiring win. That was my plan and because I made a great approach from 60 yards, it put more pressure on Jobim,” said Pagunsan, who came from an ACL injury. Pangunsan seemed headed to victory in regulation after shaking off Korean Kim Joo Hyung early and then going 2-up over Carlos with a clutch birdie on No. 14 coupled with Carlos’ bogey on the next.But Carlos refused to give up as he came through with that fiery windup to stun Pagunsan. But Pagunsan opted for a rather conservative play off the No. 1 tee, hacking out a superb approach shot then banging in the pressure-packed, title-clinching birdie putt.Jhonnel Ababa finished on third place at 273 after a 67, Zanieboy Gialon was on fourth with a 70 for fourth at 275 while the 16-year-old Kim limped with a three-over 73 and dropped to fifth at 277.Anthony Fernando rallied with a 67 to tie for sixth with American Pete Vilairatana and Elmer Salvador, who both carded 70s, and Elmer Salvador, who stumbled with a 71, at 278./PN
Related TopicsAlex GordonMLB Winter MeetingsTigersYoenis Cespedes Matt Loede has been a part of the Cleveland Sports Media for over 21 years, with experience covering Major League Baseball, National Basketball Association, the National Football League and even high school and college events. He has been a part of the Cleveland Indians coverage since the opening of Jacobs/Progressive Field in 1994, and spent two and a half years covering the team for 92.3 The Fan, and covers them daily for Associated Press Radio. You can follow Matt on Twitter HERE. Matt Loede UPDATE 6:40pm – The threat of the Tigers adding one of the big name outfielders is over according to GM Al Avila.Tigers GM Al Avila tells Detroit reporters that they are out of Cespedes and Alex Gordon talks. #Tigers— Bob Nightengale (@BNightengale) December 7, 2015NASHVILLE – The 2015 MLB Winter Meetings are in high gear in Nashville, and one of the teams the Indians have to contend with in the AL Central are already looking to reload.After a down season in 2015, word is the Tigers are looking at two possible outfielders who are both free agents, Yoenis Cespedes and Alex Gordon, this according to CBS Sports’ Jon Heyman. Detroit, who last season stumbled to an 74-87 season, traded Cespedes to the Mets after they felt their season was all but over.Before they moved him, he hit .293 with 18 homers and 61 RBI. As for Gordon, who won a World Series ring with the Royals last year, he hit .271 with 13 homers and 48 RBI in 104 games.There’s no doubt that Detroit wants to make a splash at these meetings, and are willing to pay big to do it.
Antonio Rudiger has added to Maurizio Sarri’s problems by comparing the beleaguered Chelsea manager’s intense training methods to being at school.Sarri is fighting to save his job after a dismal first season in charge at Stamford Bridge.A tame FA Cup fifth-round defeat against Manchester United on Monday was the latest setback for Sarri, who has seen Chelsea suffer humiliating defeats against Manchester City and Bournemouth in recent weeks.In a bid to cram in extra work on his football philosophy for players reported to be unconvinced by his plans, Sarri has introduced training on match days.And Chelsea’s Germany defender Rudiger admitted the sessions can be a psychological challenge.“It’s not like we are doing box to box runs. It’s not physical. It’s just the tactical things he likes to do,” Rudiger told reporters.“It’s the same if you sit in the school the whole time listening to someone. Of course, sometimes, it gets mental, but at the end of the day you have to do your job.”Chelsea fans turned on Sarri during the United game, criticising the possession-based style the Italian favours and calling for him to be sacked.Amid reports he would be dismissed if Chelsea lose any of their next three matches, Sarri bemoaned a lack of time to spark a turnaround.Thursday’s visit of Malmo in the Europa League last-32 second leg is followed by Sunday’s League Cup final against Manchester City and a London derby with Tottenham in the Premier League on February 27.While Rudiger and his team are focused on defending their 2-1 first-leg lead against Malmo, he conceded Chelsea face a season-defining moment at Wembley on Sunday.“First of all, let’s speak about the game tomorrow because it’s important for us to stay in this competition and fight to win it,” he said.“Then, on Sunday, a big game against City at Wembley. That will show the truth. That will show our way this season.“The truth in terms of keeping up with opponents like City, and also Liverpool and Tottenham.“You always play for your manager, but you want results. You want to win. No player on earth likes to have the kind of run we’ve had.”